The endocannabinoid system has very widespread effects throughout the body and has the potential to be used therapeutically and medicinally. Research suggests that cannabidiol (CBD) may be helpful as a therapeutic treatment for certain neurological conditions.
5 Ways CBD Affects Your Brain
Cannabidiol (CBD) is a non-psychoactive chemical made by cannabis plants. In most cannabis plants, CBD is the second most common chemical produced. THC is the most common chemical produced by most cannabis plants. Though many people think about THC when they think about marijuana, CBD is becoming more popular due to its numerous health benefits.
Relieves Anxiety and Depression
Many people are familiar with marijuana’s ability to help alleviate anxiety. While THC helps some people feel more relaxed and calm, it can actually increase anxiety in other people. This has led researchers to examine CBD as a treatment for anxiety and depression instead.
For instance, in one study, researchers examined the effects of CBD on the brain and anxiety levels. The researchers discovered that CBD reduces blood flow to areas of the brain linked with anxiety, such as the hypothalamus, which usually become overactive in people with anxiety disorders. It was also found that CBD reduced overall anxiety, with participants reporting lower anxiety levels after having received the chemical.
CBD may also be effective as an antidepressant. CBD appears to work by balancing the dysfunction in the endocannabinoid system in people with depression. Additionally, CBD has been found to work on a serotonin receptor that influences depression symptoms.
These studies have opened doors for both patients and clinicians. While antidepressants can take weeks to work and cause side effects, CBD works immediately without many side effects.
Protects Brain Cells from Harm
Although many believe that marijuana damages the brain, studies indicate that some components of cannabis, such as CBD, can actually protect brain cells from harm. In fact, in 1999, the United States Department of Health and Human Services actually obtained a patent for the neuroprotective effects of cannibinoids. The patent states that cannabis and its chemical properties can protect brain cells in individuals with neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and other types of dementia.
CBD’s neuroprotective effects are related to its effect on CB2 receptors in the brain. CBD acts on CB2 receptors to create anti-inflammatory responses in immune cells located in the brain. This reduces the extent to which damage to the brain is caused by inflammation.
Oxidation contributes to brain tissue damage and is partly responsible for the brain damage seen in individuals with conditions like Parkinson’s disease and Alzheimer’s disease. Research indicates that CBD acts on CB2 receptors to decrease oxidative damage.
Activates the Endocannabinoid System
The endocannabinoid system is comprised of CB1 receptors, which are mainly located in the brain, and CB2 receptors, which are mostly located on immune cells. Chemicals like THC and CBD activate the endocannabinoid system when marijuana is consumed. THC binds with CB1 receptors in the brain, producing psychoactive effects, such as pain relief, heightened mood, short-term memory impairments, and hunger.
Unlike THC, CBD does not activate CB1 receptors. That’s why CBD doesn’t have any psychoactive effects. Rather, CBD interacts with CB1 receptors in a way that inhibits chemicals, such as THC, from binding to CB1 receptors. CBD decreases many of the psychoactive effects THC can have, such as memory problems and anxiety.
Additionally, CBD increases anandamide levels within the brain. Anandamide is one of the few natural cannabinoids made in the body. Anandamide has a part in regulating other chemicals in the brain like dopamine and serotonin.
Relieves Inflammation and Pain
Cannabis has been used to alleviate pain for thousands of years. While the pain-killing ability of THC has long been known, studies indicate that CBD can effectively relieve pain as well. CBD helps manage pain by acting on CB2 receptors, which are mainly located on immune cells. The CB2 receptors are responsible for managing some cellular functions.
One of the cellular functions CB2 receptors are responsible for managing is suppressing the inflammation response created by immune cells. CBD decreases the amount of inflammatory molecules, such as chemokines and cytokines, that are present at sites of inflammation. CBD’s ability to decrease inflammation peripherally helps block pain signals from going to the brain.
Fights Psychosis and Seizures
CBD can also be effective in managing epilepsy. CBD seems to manage seizures by lowering the degree of excitation of cells in the brain that play a part in seizures. CBD stops the brain mechanisms that contribute to seizures by enhancing the release of the inhibitory neurotransmitter GABA.
CBD also has antipsychotic effects. CBD increases anandamide in the brain. Increased levels of anandamide in the brain have been associated with decreases in psychotic symptoms.
CBD possesses numerous health benefits and can help manage both medical and mental health conditions. If you are interested in using cannabis to help manage your health, please call LifeBoost to pre-qualify for the use of medical cannabis.
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Article written by
Tina Magrabi Senior Content Writer
Tina Magrabi is a writer and editor specializing in holistic health. She has written hundreds of articles for Weedmaps where she spearheaded the Ailments series on cannabis medicine. In addition, she has written extensively for the women’s health blog, SafeBirthProject, as well as print publications including Destinations Magazine and Vero’s Voice. Tina is a Yale University alumna and certified yoga instructor with a passion for the outdoors.
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