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jimson weed seeds effects

Pinilla, Llorente B., Portillo, A., Muino, Miguez A., and Garcia, Castano J. [Datura stramonium poisoning]. An.Med.Interna 1992;9(4):208. View abstract.

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Gdyra, D. and Zweglinska-Pioro, A. [Datura stramonium poisoning]. Pol.Tyg.Lek. 5-18-1970;25(20):733-735. View abstract.

Interactions

Some of these drying medications include atropine, scopolamine, and some medications used for allergies (antihistamines), and for depression (antidepressants).

Rissech, Payret M. and Garcia, Tornel S. [Datura stramonium poisoning]. Med.Clin.(Barc.) 11-25-1979;73(9):397. View abstract.

Jimenez-Mejias, M. E., Fernandez, A., Montano-Diaz, M., and Gonzalez de la Puente MA. [Anticholinergic syndrome from poisoning by Datura stramonium]. Med.Clin.(Barc.) 7-6-1991;97(6):237. View abstract.

Kotwica, M. and Czerczak, S. The pattern of poisonings with substance of abuse in Poland (1997-1998). Przegl.Lek. 2001;58(4):237-239. View abstract.

Jimson weed (Datura stramonium, a member of the Belladonna alkyloid family) is a plant growing naturally in West Virginia and has been used as a home remedy since colonial times. Due to its easy availability and strong anticholinergic properties, teens are using Jimson weed as a drug. Plant parts can be brewed as a tea or chewed, and seed pods, commonly known as “pods” or “thorn apples,” can be eaten. Side effects from ingesting jimson weed include tachycardia, dry mouth, dilated pupils, blurred vision, hallucinations, confusion, combative behavior, and difficulty urinating. Severe toxicity has been associated with coma and seizures, although death is rare. Treatment consists of activated charcoal and gastric lavage. Esmolol or other beta-blocker may be indicated to reduce severe sinus tachycardia. Seizures, severe hypertension, severe hallucinations, and life-threatening arrhythmias are indicators for the use of the anticholinesterase inhibitor, Physostigmine. This article reviews the cases of nine teenagers who were treated in hospitals in the Kanawha Valley after ingesting jimson weed. We hope this article will help alert primary care physicians about the abuse of jimson weed and inform health officials about the need to educate teens about the dangers of this plant.

Grandjean, E. M., de Moreloose, P., and Zwahlen, A. [Acute atropinic syndrome caused by abuse of anti-asthmatic cigarettes (Datura stramonium)]. Schweiz.Med.Wochenschr. 8-16-1980;110(33):1186-1190. View abstract.

Suda, K., Komatsu, K., and Hashimoto, K. A histopathological study on the islets of Langerhans and ductal epithelial metaplasia in atrophic lobuli of pancreas. Acta Pathol.Jpn. 1976;26(5):561-572. View abstract.

Taha, S. A. and Mahdi, A. H. Datura intoxication in Riyadh. Trans.R.Soc.Trop.Med.Hyg. 1984;78(1):134-135. View abstract.

Special Precautions and Warnings

Groszek, B., Gawlikowski, T., and Szkolnicka, B. [Self-poisoning with Datura stramonium]. Przegl.Lek. 2000;57(10):577-579. View abstract.

Shervette, R. E., III, Schydlower, M., Lampe, R. M., and Fearnow, R. G. Jimson "loco" weed abuse in adolescents. Pediatrics 1979;63(4):520-523. View abstract.

Boumba, V. A., Mitselou, A., and Vougiouklakis, T. Fatal poisoning from ingestion of Datura stramonium seeds. Vet.Hum.Toxicol. 2004;46(2):81-82. View abstract.

Mikolich, J. R., Paulson, G. W., and Cross, C. J. Acute anticholinergic syndrome due to Jimson seed ingestion. Clinical and laboratory observation in six cases. Ann.Intern.Med. 1975;83(3):321-325. View abstract.