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CBD Oil and MS: Is Cannabis Oil a Miracle for Multiple Sclerosis?

CBD — short for cannabidiol — has a long list of well-documented health benefits. People use CBD oil to improve general well-being and to alleviate a wide range of symptoms, from anxiety to pain, inflammation, and neurological problems.

However, some areas where CBD could potentially help, are yet to be thoroughly examined.

Such is the case of using CBD oil for multiple sclerosis (MS).

Many MS patients are successfully taking cannabidiol, claiming it helps with their symptoms and repairs damaged nerves.

Current research shows that extracts like CBD oil can be effective in reducing pain and spasms in MS patients.

But can CBD oil actually treat multiple sclerosis?

Unfortunately, the research is still inconclusive. In this article, we’ll cover the most important aspects of using CBD oil for MS — including the benefits, different consumption methods, and possible side effects.

What is Multiple Sclerosis?

Multiple Sclerosis is a self-aggressive disease where the body’s immune system attacks the central nervous system (CNS). Scientists are still trying to discover the exact cause of MS; however, the general consensus is that this disease may be triggered by a combination of genetic and environmental factors.

Currently, about 2.3 million people in the US suffer from MS. The majority of diagnosed patients are between their 20s and 50s — it’s unclear why some people have this condition while others don’t.

Multiple Sclerosis damages the protective layer around nerve fibers (myelin). When the CNS notices the patches of scars left behind by an aggressive immune system, it starts to send false signals to the brain — leading to an array of symptoms.

In some people, these symptoms are relatively mild like extensive fatigue, while other cases involve severe pain, involuntary muscle cramps, impaired memory and focus, and vision problems.

When left untreated, multiple sclerosis may result in partial or complete paralysis.

Types of Multiple Sclerosis

There are 4 main forms of multiple sclerosis based on the type and severity of symptoms:

Relapsing-Remitting (RRMS)

This is the most prevalent type of MS and affects about 85% of patients diagnosed with MS.

People with RRMS suffer from periodical fare-ups that exacerbate their symptoms, followed by silent periods where the patient remains symptom-free until the next flare-up.

Secondary-Progressive (SPMS)

For SPMS sufferers, symptoms deteriorate over time but without flare-ups. In most cases, RRMS transforms into SPMS.

Primary-Progressive (PPMS)

A less common form of MS, primary-progressive multiple sclerosis affects about 10% of all MS patients.

This form of the disease is marked by worsening symptoms from the beginning, without flare-ups or remissions typical to other types of MS.

Progressive-Relapsing (PRMS)

This is the rarest form of MS and occurs in about 5% of MS sufferers. The symptoms of PRMS worsen steadily over time, with flare-ups and acute relapses but without remission periods.

What is CBD Oil?

CBD oil is a concentrated CBD extract made from cannabis plants — both hemp and marijuana.

CBD is a cannabinoid — a naturally occurring phytochemical — and the second-most recognized active ingredient of cannabis.

Unlike the most popular cannabinoid, delta-9-tetrahydrocannabinol (THC), CBD is non-psychoactive and thus won’t get you high. This makes CBD legal in most countries across the world.

The lack of psychoactive effects doesn’t make it an inferior cannabinoid. On the contrary, CBD has a long list of well-documented health benefits with only a few mild side effects. Cannabis advocates argue that CBD can help with virtually any condition deriving from a compromised endocannabinoid system (ECS) — the prime neurochemical network in our bodies.

Most CBD stuff sold online and in local dispensaries comes from hemp plants, which takes us to the next question.

How is CBD Hemp Oil Different from Medical Marijuana?

The main difference between CBD from hemp and medical marijuana is the aforementioned THC content.

Hemp plants are high in CBD and very low in THC. The THC content of hemp plants is usually below 0.3%, which isn’t enough to produce any psychoactive effects.

On the other hand, marijuana has high THC levels and doesn’t offer much CBD. However, some strains are specifically bred to achieve higher CBD levels at the cost of some THC.

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Still, you won’t buy marijuana products in your local head shop or health store as marijuana remains a controlled substance according to federal law. You can buy medical marijuana if you live in a state that runs a medical marijuana program.

CBD oil from hemp is legal in all 50 states. You can find it in cannabis dispensaries, head shops, and online stores. You don’t need a doctor’s prescription to try CBD oil for multiple sclerosis.

Different Ways to Take CBD Oil for Multiple Sclerosis

If you’re considering trying CBD oil for your MS symptoms, it is available in the form of oil drops, tinctures, sprays, capsules, and edibles, which can be ingested, as well as vape products and creams for topical use.

Can CBD Oil Help With Multiple Sclerosis?

Dr. Ben Thrower, a physician at the Shepherd Center in Atlanta, GA, is very optimistic about using CBD oil for multiple sclerosis, but at the same time, he underlines the importance of THC in the treatment.

“Many of our MS patients have used hemp-based CBD products with 0.3 percent THC or less (…) For the management of spasticity/spasms or burning pain (central neuropathic pain), I have found that most patients need higher THC concentrations.”

THC is a well-known pain reliever — this may explain the need for higher levels of THC in CBD products for treating MS symptoms.

However, Thrower points to CBD topicals as a potential solution for fighting localized pain in MS patients

“Some patients do find relief with Low-THC, CBD lotions applied topically,” said Thrower.

What Does the Research Say About Using CBD Oil for Multiple Sclerosis

In a 2009 study, researchers investigated previous reports from MS patients who used cannabis for their symptoms to find out whether a mix of CBD and THC may reduce spasticity associated with MS.

Each of the analyzed papers focused on testing THC and CBD in capsules and oral sprays. These products generally involved more THC than CBD, which resulted in a trend of reduced spasticity.

Researchers also concluded that THC/CBD solutions are well tolerated by patients and that the experienced side effects didn’t always stem from using cannabis alone.

In 2016, researchers were looking at how a pharmaceutical spray Sativex might reduce muscle spasms in MS sufferers.

Sativex is an oral solution made from CBD and THC in a 1:1 ratio. The spray was developed to reduce neuropathic pain, overactive bladder, spasticity, and other common symptoms of multiple sclerosis.

Researchers examined self-reported data from several hundred MS patients who were using the drug for one year. Results showed a 20% improvement in muscle spasticity for 70% of subjects and a 30% improvement in 28% of patients.

For about 39% of patients, the treatment was ineffective. Although those patients dropped out of the study, the results do provide evidence to support further research on cannabinoids for multiple sclerosis.

Finally, there’s a 2018 research review that analyzed existing studies to find indirect that CBD, along with other cannabinoids, can improve the mobility of MS patients.

The paper focused mostly on a high CBD to THC ratio as the potential reliever of muscle spasms and pain in MS patients. It also discussed how cannabis reduces inflammation, contributing to less fatigue in subjects.

Because CBD oil may be able to alleviate so many symptoms of multiple sclerosis — pain, spasticity, inflammation, and fatigue — it’s reasonable to assume that CBD can have a positive impact on mobility in MS patients.

What Are the Side Effects of Using CBD Oil for Multiple Sclerosis?

When it comes to unwanted reactions to CBD, Thrower said there are very few. They’re also uncommon and generally considered mild.

“I have found the side effect profile of these products to be less than some of the prescription medications,” he added. “CBD/THC products tend to be far less sedating than Baclofen or Tizanidine, which are [muscle relaxants] traditionally used for spasticity,” he added.

Most often, taking too much CBD oil results in a dry mouth, lowered blood pressure, and dizziness. In very rare cases, high doses of CBD oil can trigger diarrhea.

Key Takeaways: What You Need to Know About Using CBD Oil for MS

So, there you have it — everything we know about using CBD oil for MS so far.

Let’s summarize the article in a nutshell:

  • CBD can be effective in reducing pain and spasms in multiple sclerosis patients
  • However, CBD alone has limited potential for relieving MS.
  • It appears that adding THC significantly improves the therapeutic properties of CBD
  • Some people can have negative reactions to the psychoactive effects of THC, especially if their symptoms call for higher doses of medical cannabis oil.
  • Moreover, equal ratios of CBD to THC may not work for certain people, as studies have shown.
  • Full-spectrum cannabis extracts with higher ratios of CBD to THC may be able to relieve a wider range of symptoms and improve mobility in MS patients.
  • Hemp-derived CBD topicals may be effective in reducing localized pain and inflammation during flare-ups.

I hope this article has helped you understand how cannabinoids work for specific MS symptoms. As always, make sure to contact your GP before taking any CBD product, especially if you’re already taking prescribed medications cannabidiol can interact with.

Nina Julia

Nina created CFAH.org following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.

CBD for MS (Multiple Sclerosis) – August 2022

According to The National Multiple Sclerosis Society, approximately 85% of people with MS are initially diagnosed with relapsing-remitting MS (RRMS) (5 ) .

RRMS is a type of MS characterized by inflammatory attacks on the nerve fibers and myelin, the layers of insulating membranes surrounding nerve fibers in the central nervous system (CNS).

While RRMS is defined by attacks or relapses of new MS symptoms, progressive forms of MS involve fewer attacks.

The progressive types of MS are secondary-progressive MS (SPMS), primary-progressive MS (PPMS), and progressive-relapsing MS (PRMS).

The symptoms of MS vary, but they often include pain, inflammation, muscle spasticity, MS fatigue, and depression.

Spasticity is a condition characterized by an abnormal increase in muscle tone or stiffness of muscle, which might interfere with movement.

MS symptoms can reduce physical activity, negatively impact functional mobility, and have a detrimental effect on a person’s quality of life (6) .

Although there have been recent significant advances in disease-modifying therapy, none of the current treatments stops or cures MS-related symptoms (7 ) .

Thus, many people with MS look for alternative and complementary therapies, such as cannabis plants and their derivatives.

CBD for Multiple Sclerosis: What The Research Says

Sativex is a cannabis-based prescription medicine that contains a 1:1 CBD (cannabidiol)-THC (delta-9-tetrahydrocannabinol) ratio.

Approved as an additional treatment for nerve pain and spasticity in multiple sclerosis patients, Sativex is administered as a mouth spray (oromucosal) (8 ) .

In a 2005 study published in Issues in Emerging Health Technologies , 368 patients with various neurological conditions, including MS, were given the THC:CBD spray (9 ) .

Results showed that the spray significantly reduced nerve pain, spasticity, muscle spasms, and sleep disturbances among the human subjects.

However, the researchers observed adverse events, like dizziness, sleepiness, fatigue, feeling of intoxication, and experiencing an unpleasant taste.

A 2016 study in Therapeutic Advances in Neurological Disorders summarized the evidence for the efficacy and effectiveness of THC-CBD oromucosal spray in symptom management for those experiencing spasticity due to MS (10 ) .

Researchers believe that for individuals with resistant moderate to severe MS-induced spasticity, THC-CBD spray can be a treatment option.

It was only in 2017 when a pre-clinical study on CBD alone was conducted. The study, published in CNS and Neurological Disorders – Drug Targets, showed that CBD could produce beneficial effects in individuals with MS (11 ) .

How CBD Oil Works to Help With Multiple Sclerosis

The two primary cannabinoid receptors are CB1 and CB2. CB1 receptors are found in the CNS (the brain and spinal cord), intestines, connective tissues, and other glands.

CB2 receptors are mostly located in the spleen, tonsils, and immune cells. Only a few are in the brain.

Data suggests that CBD does bind to the receptors but does not directly activate them. Instead, it appears to adjust how the receptors respond to stimulation from other compounds, such as THC (12 ) .

The authors of a study, published in the British Journal of Pharmacology in 2010, noted there had been anecdotal and scientific evidence of cannabis providing symptomatic relief in neurodegenerative disorders, including MS (13 ) .

The study results implied that the endocannabinoid system (ECS) impairment might be responsible for some disease symptoms.

The ECS plays an active role in regulating a wide range of body functions, including pain sensation, immune response, anxiety , mood, appetite, sleep, metabolism, and memory.

The CBD-THC spray, Sativex, acts via cannabinoid receptors distributed throughout the CNS and in immune cells (14 ) .

CB2 is involved in weakening inflammatory immune cell response to disease.

Meanwhile, the activation of CB1 receptors has been shown to block the release of glutamate, a chemical transmitter released by nerve cells in the brain (15 ) .

Abnormal or excessive glutamate levels and signaling in the nervous system can contribute to MS (16 ) .

The Pros and Cons of CBD Oil for Multiple Sclerosis

Pros
  • Evidence suggests that CBD may reduce MS symptoms, such as MS fatigue, pain, and spasticity, and ultimately improve mobility (17 ) .
  • The 2018 Farm Bill has legalized CBD products derived from hemp. However, individual states in the United States have their legislation (18 ) .
  • The American Academy of Neurology has highlighted the safety profile and benefits of cannabis in a review of medical marijuana (medical cannabis).

The review was conducted to address the treatment of symptoms of MS, epilepsy, and movement disorders (19 ) .

  • No studies have investigated the effects of cannabis oil on mobility in individuals with MS. However, some studies have suggested that CBD may exert positive effects on health by reducing inflammation and relieving pain (20 ) .
Cons
  • Studies are too limited to determine if CBD is an effective treatment for conditions other than those approved by the US Food and Drug Administration (FDA).
  • There are risks in using CBD. Possible side effects include dry mouth, drowsiness, diarrhea, fatigue, and reduced appetite (21 ) .
  • CBD can interact with other drugs and alter how the body metabolizes certain medications, as a 2017 research noted (22 ) .
    • A 2017 review revealed labeling inaccuracies in some CBD products. Some products had less CBD than stated in the label, while others had more (23 ) .

    How CBD Oil Compares to Alternative Treatments for Multiple Sclerosis

    Some of the alternative or complementary therapy options for MS include massage and a healthy, well-balanced diet with linoleic acid supplementation (24 ) .

    Regular massage therapy can help MS patients relax and reduce stress and depression, which can exacerbate the disease.

    CBD oil tinctures can be combined with massage oils. Like massage oils, CBD-infused bath bombs can help provide relaxation and relief from physical tension and emotional stress.

    A study published in the journal CNS and Neurological Disorders – Drug Targets noted that CBD had therapeutic uses as an anti-anxiety-like and an antidepressant-like compound (25 ) .

    There is also evidence that taking an oral supplement of linoleic acid (found in evening primrose oil) may improve MS symptoms.

    Researchers of a 2019 study found that higher levels of α-linolenic acid (ALA) were associated with lower disease activity in MS patients (26 ) .

    Meanwhile, cannabis extracts from Sativa cultivars (Cannabaceae) are rich in linoleic acid (57.1%), according to researchers of a 2012 study published in the European Journal of Lipid Science and Technology (27 ) .

    How to Choose the Right CBD

    Consider the following to ensure the reliability and safety of the CBD products purchased.

        1. Research on the legal stipulations applicable to CBD in the area where it would be bought and used.
        2. Read product reviews before buying from an online store. Check if the store is authorized by the government to sell CBD.
        3. Look for the certificate of analysis (COA) of the CBD product. A COA is a laboratory report that includes cannabinoid content and other tested compounds.
        4. Compare company claims with that of third-party lab testing reports.

      CBD Dosage for Multiple Sclerosis

      The appropriate dose of cannabinoids for specific medical conditions is not known . However, there are suggested doses for some multiple sclerosis symptoms, like pain and spasticity.

      A 2011 systematic review that examined the effects of cannabinoids of any type (smoked cannabis, oral extracts, nabilone, synthetic THC, nabiximols) showed that cannabinoids provided pain relief (28 ) .

      When using Sativex for the first time for MS-related pain and spasticity, follow the number of sprays on the days and times in the table below as reference (29 ) .

      Each 100 microlitre spray contains 2.7 mg THC and 2.5 mg CBD.

      (Between waking up and noon)

      (Between 4 pm and bedtime)

      A 2011 study noted that high doses of 1,500 mg CBD a day is well-tolerated by humans (30 ) . Still, always consult with a doctor before taking any CBD products.

      How to Take CBD Oil for Multiple Sclerosis

      A topical CBD cream or patch is ideal to use for inflammation or pain in a specific area. The CBD can target localized clusters of cannabinoid receptors, rather than interacting with the entire endocannabinoid system (ECS).

      CBD oil capsules and edibles, such as gummies , brownies, and lozenges, are a convenient and straightforward way to take CBD oil, especially for beginners.

      Meanwhile, CBD oil tinctures and sprays may be practical options for those who seek fast results and maximum dosage control.

      Conclusion

      CBD alone or its combination with another cannabinoid, like THC, may help alleviate many common MS symptoms.

      Unfortunately, studies on the use of CBD for specific medical conditions in humans are limited, and CBD’s long-term effects remain unknown.

      More longitudinal research is required to gather more scientific evidence and validate results from previous studies.

      Consulting with a doctor experienced in CBD use is ideal before using CBD or any cannabis products.

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